Fri 02 Feb 13:00: Group Discussion - What I wish I had Known Earlier in My Research Career
Abstract not available
- Speaker: Group Discussion
- Friday 02 February 2024, 13:00-14:00
- Venue: FW11, William Gates Building. Zoom link: https://cl-cam-ac-uk.zoom.us/j/4361570789?pwd=Nkl2T3ZLaTZwRm05bzRTOUUxY3Q4QT09&from=addon .
- Series: Energy and Environment Group, Department of CST; organiser: lyr24.
Fri 22 Mar 13:00: Title - TBC
This Cambridge Immunology and Medicine Seminar will take place on Friday 22 March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC):
Speaker: Dr Sara Ghorashian, Honorary Senior Clinical Lecturer, University College London and Consultant Paediatric Haematologist, Great Ormond Street Hospital
Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology, University of Cambridge.
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom Refreshments will be available following the Seminar.
This talk is part of the Immunology and Medicine Seminars series.
If you have a question about this talk, please contact Ruth Paton
- Speaker: Sara Ghorashian, Honorary Associate Professor, University College London
- Friday 22 March 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Fri 08 Mar 13:00: Title - TBC
The next Cambridge Immunology and Medicine Seminar will take place on Friday 8th March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)
Speaker: Professor Luca Gattinoni, Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy
Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology (Department of Pathology) and Director (non-clinical) of the CRUK Cambridge Centre Training Programme, at the University of Cambridge.
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:
Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09
Meeting ID: 897 4163 4903 Passcode: 539740
Refreshments will be available following the Seminar.
- Speaker: Luca Gattinoni, Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
- Friday 08 March 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Reconfigurable Growth of Engineered Living Materials
The growth of multicellular organisms is a process akin to additive manufacturing where cellular proliferation and mechanical boundary conditions, amongst other factors, drive morphogenesis. Engineers have limited ability to engineer morphogenesis to manufacture goods or to reconfigure materials comprised of biomass. Herein, a method that uses biological processes to grow and regrow magnetic engineered living materials (mELMs) into desired geometries is reported. These composites contain Saccharomyces cerevisiae and magnetic particles within a hydrogel matrix. The reconfigurable manufacturing process relies on the growth of living cells, magnetic forces, and elastic recovery of the hydrogel. The mELM then adopts a form in an external magnetic field. Yeast within the material proliferate, resulting in 259 ± 14% volume expansion. Yeast proliferation fixes the magnetic deformation, even when the magnetic field is removed. The shape fixity can be up to 99.3 ± 0.3%. The grown mELM can recover up to 73.9 ± 1.9% of the original form by removing yeast cell walls. The directed growth and recovery process can be repeated at least five times. This work enables ELMs to be processed and reprocessed into user-defined geometries without external material deposition.
This article is protected by copyright. All rights reserved
Dibromomethane Knitted Highly Porous Hyper‐Cross‐Linked Polymers for Efficient High‐Pressure Methane Storage
Hyper-cross-linked polymers (HCPs) with ultra-high porosity, superior physicochemical stability and excellent cost-effectiveness are attractive candidates for methane storage. However, the construction of HCPs with BET surface areas exceeding 3000 m2 g–1 remains extremely challenging. In this work, a newly developed DBM-knitting method with a slow-knitting rate was employed to increase the crosslinking degree, in which dichloromethane (DCM) was replaced by dibromomethane (DBM) as both solvent and electrophilic cross-linker, resulting in highly porous and physicochemically stable HCPs. The BET surface areas of DBM-knitted SHCPs-Br are 44%–120% higher than that of DCM-knitted SHCPs-Cl using the same building blocks. Remarkably, SHCP-3-Br exhibits an unprecedentedly high porosity (SBET = 3120 m2 g–1) among reported HCPs, and shows a competitive volumetric 5–100 bar working methane capacity of 191 cm3 (STP) cm–3 at 273 K calculated by using real packing density, which outperforms sate-of-art MOFs at comparable condtions. This facile and versatile low-knitting-rate strategy enables effective improvement in the porosity of HCPs for porosity-desired applications.
This article is protected by copyright. All rights reserved
Thu 06 Jun 16:00: Title to be confirmed
Abstract not available
- Speaker: Colleen Deane, University of Southampton
- Thursday 06 June 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 23 May 16:00: Title to be confirmed
Abstract not available
- Speaker: Stefanie Wculek, IRB (Biomedical Research Institute, Barcelona)
- Thursday 23 May 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 09 May 16:00: Title to be confirmed
Abstract not available
- Speaker: Shankar Srinivas, Oxford University
- Thursday 09 May 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 25 Apr 16:00: Title to be confirmed
Abstract not available
- Speaker: Laura Machesky, Department of Biochemistry, University of Cambridge
- Thursday 25 April 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 14 Mar 16:00: Title to be confirmed
Abstract not available
- Speaker: Miguel Torres, Spanish National Center for Cardiovascular Research
- Thursday 14 March 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 14 Mar 16:00: Title to be confirmed
Abstract not available
- Speaker: Miguel Torres, Spanish National Center for Cardiovascular Research
- Thursday 14 March 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 29 Feb 16:00: Title to be confirmed
Abstract not available
- Speaker: Susan Ozanne, MRC, University of Cambridge
- Thursday 29 February 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 29 Feb 16:00: Title to be confirmed
Abstract not available
- Speaker: Susan Ozanne, MRC, University of Cambridge
- Thursday 29 February 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Fri 16 Feb 13:00: Mechanisms controlling gene expression in hypoxia and inflammation
Professor Sonia Rocha, Executive Dean of the Institute of Systems Molecular and Integrative Biology, University of Liverpool.
The next Cambridge Immunology and Medicine Seminar will take place on Friday 16th February 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)
Host: Professor James Nathan, Wellcome Senior Clinical Fellow, Professor of Respiratory Medicine, University of Cambridge.
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:
Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09
Meeting ID: 897 4163 4903 Passcode: 539740
Refreshments will be available following the Seminar.
If you have a question about this talk, please contact Ruth Paton.
- Speaker: Professor Sonia Rocha, Executive Dean of the Institute of Systems Molecular and Integrative Biology, University of Liverpool
- Friday 16 February 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Thu 15 Feb 16:00: Towards Human Systems Biology of Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep
The field of human biology faces three major technological challenges. Firstly, the causation problem is difficult to address in humans compared to model animals. Secondly, the complexity problem arises due to the lack of a comprehensive cell atlas for the human body, despite its cellular composition. Lastly, the heterogeneity problem arises from significant variations in both genetic and environmental factors among individuals. To tackle these challenges, we have developed innovative approaches. These include 1) mammalian next-generation genetics, such as Triple CRISPR for knockout (KO) mice and ES mice for knock-in (KI) mice, which enables causation studies without traditional breeding methods; 2) whole-body/brain cell profiling techniques, such as CUBIC , to unravel the complexity of cellular composition; and 3) accurate and user-friendly technologies for measuring sleep and awake states, exemplified by ACCEL , to facilitate the monitoring of fundamental brain states in real-world settings and thus address heterogeneity in human.
By integrating these three technologies, we have made significant progress in addressing two major scientific challenges in sleep research: 1) understanding sleep regulation (sleep mechanisms) and 2) determining the role of sleep (sleep functions). With regard to sleep mechanisms, we have recently proposed the phosphorylation hypothesis of sleep, which emphasizes the role of the sleep-promoting kinase CaMKIIα/CaMKIIβ (Tatsuki et al., 2016; Tone et al., 2022; Ode et al., 2020) and the involvement of calcium signaling pathways (Tatsuki et al., 2016). According to this novel perspective, the dynamics of calcium, representing neural activity during wakefulness, can be integrated and converted into the auto-phosphorylation status of CaMKIIα/CaMKIIβ, which induces and sustains sleep (Tone et al., 2022). Concerning sleep functions, we conducted computational studies to examine synaptic efficacy dynamics during sleep and wakefulness. Our findings led to the formulation of the Wake-Inhibition-Sleep-Enhancement (WISE) hypothesis, suggesting that wakefulness inhibits synaptic efficacy, while sleep enhances it.
During this talk, we will also present our discoveries regarding the identification of muscarinic acetylcholine receptors (Chrm1 and Chrm3) as essential genes of REM sleep. Furthermore, we will discuss new insights into psychiatric disorders, neurodevelopmental disorders, and neurodegenerative disorders derived from the phosphorylation hypothesis of sleep.
- Speaker: Dr Hiroki Ueda, University of Tokyo
- Thursday 15 February 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Mon 26 Feb 13:00: Data-Driven and Equation-Informed Optimal Control of Lagrangian pairs in turbulent flows
We show how to apply optimal control theory to catch a passive drifting target in a turbulent flow by an autonomous flowing agent with limited maneuverability. For the case of a perfect knowledge of the environment, we show that Optimal Control theory can overcome chaotic dispersion capturing the Lagrangian target in the shortest possible time [1]. We also provide baselines using heuristic policies based on local-only hydrodynamical cues [2]. How to extend this approach to model-free Reinforcement Learning tools is also briefly discussed [3]. Data are open downloadable from TURB Lagr [4], a database of more than 300K three-dimensional trajectories of tracer particles advected by a fully developed homogeneous and isotropic turbulent flow.
(1) Calascibetta et al., Commun. Phys. 6, 256 (2023). (2) Monthiller et al., Phys. Rev. Lett. 129, 064502 (2022). (3) Calascibetta et al., Eur. Phys. J. E 46, 9 (2023). (4) smart-turb.roma2.infn.it
- Speaker: Chiara Calascibetta
- Monday 26 February 2024, 13:00-14:00
- Venue: MR5, CMS.
- Series: Geophysical and Environmental Processes; organiser: Prof. John R. Taylor.
Tue 30 Jan 13:10: Farming of Bones: Ethics in Bioarcheology - conversations with indigenous communities and other stakeholders with respect to Holocene Era human remains in Trinidad and Tobago Canceled
Abstract not available
Canceled
- Speaker: Chike Pilgrim, Archeology
- Tuesday 30 January 2024, 13:10-14:00
- Venue: Richard King room, Darwin College.
- Series: Darwin College Humanities and Social Sciences Seminars; organiser: Dr Stefanie Ullmann.
Thu 15 Feb 13:00: Deciphering Developmental Disorders
Abstract not available
- Speaker: Matthew Hurles, Sanger Institute
- Thursday 15 February 2024, 13:00-14:00
- Venue: CRUK CI Lecture Theatre.
- Series: Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer; organiser: Kate Davenport.
Multiple Cations Nanoconfinement in Ultrathin V2O5 Nanosheets Enables Ultrafast Ion Diffusion Kinetics Toward High‐performance Zinc Ion Battery
A general, supramolecular self-assembly strategy is developed to intercalate unitary cation including NH4 +, Na+, K+, Mg2+, Ca2+, Zn2+, Al3+ and multiple cations (NH4 + + Na+, NH4 + + Na+ + Ca2+, NH4 + + Na+ + Ca2+ + Mg2+) in ultrathin V2O5 nanosheets. The success on multiple cations nanoconfinement enables very fast zinc ion diffusion kinetics and excellent long-term cycling stability. The optimized diffusion coefficient of zinc ion (7.5 × 10−8 cm2 s−1) in this assembly series surpasses most of the V-based cathodes reported up to date.
Abstract
Nanoconfinement of cations in layered oxide cathode is an important approach to realize advanced zinc ion storage performance. However, thus far, the conventional hydrothermal/solvothermal route for this nanoconfinement has been restricted to its uncontrollable phase structure and the difficulty on the multiple cation co-confinement simultaneously. Herein, this work reports a general, supramolecular self-assembly of ultrathin V2O5 nanosheets using various unitary cations including Na+, K+, Mg2+, Ca2+, Zn2+, Al3+, NH4 +, and multiple cations (NH4 + + Na+, NH4 + + Na+ + Ca2+, NH4 + + Na+ + Ca2+ +Mg2+). The unitary cation confinement results in a remarkable increase in the specific capacity and Zn-ion diffusion kinetics, and the multiple cation confinement gives rise to superior structural and cycling stability by multiple cation synergetic pillaring effect. The optimized diffusion coefficient of Zn-ion (7.5 × 10−8 cm2 s−1) in this assembly series surpasses most of the V-based cathodes reported up to date. The work develops a novel multiple-cations nanoconfinement strategy toward high-performance cathode for aqueous battery. It also provides new insights into the guest cation regulation of zinc-ion diffusion kinetics through a general, supramolecular assembly pathway.
Thu 01 Feb 13:10: Dancing in the sunlight: Light-responsive materials for drug delivery to energy storage
The performance of drugs can be enhanced by directing their delivery to the exact location that they are required. To achieve this, we need host materials that can encapsulate these molecules and release them on demand. In this talk, I will describe how we can build materials that change their shape, structure, and properties when we shine different types of light on them. I will show how we can use these materials to target the release of molecules, such as drugs, store solar energy and release it as heat, and even create controllable diffusion channels.
- Speaker: Bea Jones
- Thursday 01 February 2024, 13:10-14:00
- Venue: Richard King room, Darwin College.
- Series: Darwin College Science Seminars; organiser: Dr Sandra Petrus-Reurer.