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Nature Nanotechnology, Published online: 28 May 2025; doi:10.1038/s41565-025-01935-y

Tailored non-aqueous electrolyte solutions are formulated using data obtained from extensive analytical measurements and analyses. These optimized electrolytes improve the cycling performance of single-layer stack lithium metal pouch cells, particularly in lean electrolyte conditions.

Nature Nanotechnology, Published online: 26 May 2025; doi:10.1038/s41565-025-01927-y

Ferroelectric membranes of BaTiO3 can form centre-convergent polar topology domes that couple with light to generate circularly polarized beams.

Nature Nanotechnology, Published online: 23 May 2025; doi:10.1038/s41565-025-01936-x

Integrating molecular motors into amphiphilic surfactants creates light-activated, fast-spinning molecules that drive conformational changes, offering a non-thermal pathway to supramolecular polymerization.

Nature Nanotechnology, Published online: 23 May 2025; doi:10.1038/s41565-025-01933-0

An amphiphilic light-driven rotary motor is shown to form Langmuir monolayers at the air–water interface. Upon ultraviolet irradiation, the continuous rotation of the motor triggers its supramolecular polymerization and subsequent nanopatterning of the interfacial layer.

Nature Nanotechnology, Published online: 21 May 2025; doi:10.1038/s41565-025-01928-x

A nano-enabled strategy that reduces the mitochondrial content of cancer cells boosts immunotherapy outcomes in several animal cancer models.

Nature Nanotechnology, Published online: 21 May 2025; doi:10.1038/s41565-025-01909-0

Mitochondrial nanoinducers that degrade mitochondria via autophagy enhance T cell activation and tumour cell susceptibility, improving immunotherapy.

Nature Nanotechnology, Published online: 19 May 2025; doi:10.1038/s41565-025-01951-y

Polyethylene glycol (PEG) is a commonly used coating agent in nanomedicine, but there are growing concerns about its immunogenicity. Two Comment articles discuss the issue and possible alternatives to PEG.

Nature Nanotechnology, Published online: 19 May 2025; doi:10.1038/s41565-025-01922-3

Microwave-assisted tumour-derived microparticles enhance antitumour activity, safety and drug delivery, outperforming traditional ultraviolet-derived methods.

Nature Nanotechnology, Published online: 19 May 2025; doi:10.1038/s41565-025-01934-z

A dynamic Cu–Pt dual-atom catalyst supported on 1Tʹ-MoS2 can be electrically switched between single- and dual-atom configurations, enabling on-demand control for alkyne semi-hydrogenation.

Nature Nanotechnology, Published online: 19 May 2025; doi:10.1038/s41565-025-01924-1

A collagenase nanogel backpack enhances CAR-T cell therapy in pancreatic cancer by improving cell infiltration and overcoming physical barriers, enabling potent tumour regression and prolonged survival.

Nature Nanotechnology, Published online: 16 May 2025; doi:10.1038/s41565-025-01910-7

Engineering magnetic nanoparticles at the single-particle level advances nanoreactor design, enabling enhanced active sensing, targeted therapy, and catalytic activity, with broad implications for nano energy and nanomedicine applications.

Nature Nanotechnology, Published online: 16 May 2025; doi:10.1038/s41565-025-01931-2

Engineered pyroptotic vesicles formed during tumour cell pyroptosis and engineered as personalized tumour vaccines can activate a robust antitumour immune response for post-surgical tumour recurrence inhibition.

Nature Nanotechnology, Published online: 15 May 2025; doi:10.1038/s41565-025-01903-6

Liver macrophages are a major obstacle to extrahepatic drug delivery. This study identifies the receptor–ligand interactions that they use to capture circulating nanoparticles and leverages this understanding to engineer nanoparticles that escape macrophage uptake.

Nature Nanotechnology, Published online: 15 May 2025; doi:10.1038/s41565-025-01932-1

Multi-drug nanotherapy consistently outperforms single-drug therapy, multi-drug combination therapy, and single-drug nanotherapy across different experimental settings, therapy strategies and cancer types.

Nature Nanotechnology, Published online: 14 May 2025; doi:10.1038/s41565-025-01918-z

A nanopore-based enzyme-linked immunosorbent assay is developed for the single-molecule sensing of distinct current signatures from peptide probes generated on translocation through α-hemolysin after enzymatic cleavage, enabling the multiplexed detection of biomarkers in blood samples.

Nature Nanotechnology, Published online: 14 May 2025; doi:10.1038/s41565-025-01889-1

Genetic vaccines can be quickly formulated and tested but require multiple administrations to generate a durable antibody response, as in the case of protein subunit vaccines. Here SpyTag/SpyCatcher technology is used to develop a genetic vaccine encoding antigen-displaying capsid virus-like particles to enhance the immune response against the Pfs25 malaria antigen.

Nature Nanotechnology, Published online: 13 May 2025; doi:10.1038/s41565-025-01925-0

Mass vaccination using polyethylene glycol (PEG)-containing nanoparticles during the COVID-19 pandemic has resulted in cases of adverse reactions, bringing to the fore the issue of PEG immunogenicity and reinforcing the view that this polymer should be substituted with other stealth-inducing molecules. Before considering alternatives, however, it is crucial to carry out more detailed analyses of the anti-PEG antibodies, to standardize the procedures for their detection and to better contextualize their generation within different nanoformulations, routes of administration, indication, safety and efficacy. The resulting studies could guide both the future use of PEGylated nanomedicines and the synthesis of the next generation of PEG or its alternatives.

Nature Nanotechnology, Published online: 13 May 2025; doi:10.1038/s41565-025-01921-4

Synchrotron techniques can probe battery materials and devices at unprecedented scales of time and space, providing in-depth mechanistic understanding. However, the lack of standardization in synchrotron measurements and analyses can lead to biased interpretations of data and results. Here, we propose possible strategies to address the reliability, representativeness and reproducibility issues of synchrotron characterizations in battery research.

Nature Nanotechnology, Published online: 13 May 2025; doi:10.1038/s41565-025-01926-z

Developing nanomedicines that avoid fast blood clearance while retaining targeting specificity in vivo is inherently challenging. Leveraging the individual biomolecular corona, optimizing the nature of targeting ligands and exploring alternative stealth formulations might be the key to engineering tailored nanomedicine approaches.

Nature Nanotechnology, Published online: 13 May 2025; doi:10.1038/s41565-025-01915-2

A paddle-like self-stirring nanoreactor system with spatially isolated multifunctional components is successfully constructed. The rotation–revolution pattern enhances the internal and reverse dual-dynamic diffusion processes, thus effectively boosting the cascade efficiency.