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A bioinspired polymeric membrane-enclosed insulin crystal achieves long-term, self-regulated drug release for type 1 diabetes therapy
Nature Nanotechnology, Published online: 26 February 2025; doi:10.1038/s41565-025-01860-0
This article presents a polymeric membrane-enclosed insulin crystal equipped with physiological signal-sensing microdomains, dubbed ‘smart drug crystals’, that enables long-term, glucose- and β-hydroxybutyrate-dually responsive drug release for type 1 diabetes therapy.
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