http://onlinelibrary.wiley.com/rss/journal/10.1002/(ISSN)1521-4095

Nanoporous Crystalline Materials

Nanoporous crystalline materials, characterized by their highly ordered and uniform pore structures, tunable surface chemistry, and adjustable pore size, serve as exceptional platforms for nucleic acid extraction, detection, and delivery. In the review number 2305171, Xiang Zhou, Shuang Peng, and co-workers summarize recent advancements in this field. These breakthroughs highlight the innovative potential of such materials in natural science applications, including biosensing and nanomedicine, while demonstrating the interdisciplinary vitality arising from the integration of nanoporous materials with nucleic acid technologies.

Oral Diseases Therapy

In article number 2304982, Yufeng Zhang and co-workers design a novel drug carrier encapsulating both indocyanine green and rapamycin to treat and prevent biofilm-induced oral diseases by regulating the microbial-cellular microenvironment, thus providing a promising strategy for future clinical applications.

Wafer-Scale 2D Semiconductor TMDCs Single Crystals

In article number 2305115, Jianping Shi and co-workers systematically summarize the up-to-date research progress regarding the controlled synthesis and accurate doping of wafer-scale 2D semiconductor TMDCs single crystals. The challenges about the improvement of device performances of 2D semiconducting TMDCs are highlighted, and further research directions are put forward.

Artificial moiré superlattices have become a fertile playground for emergent quantum phenomena. Modern angle-resolved photoemission spectroscopy (ARPES) can directly visualize electronic structures and thus can provide enlightening insights into fundamental physics in moiré superlattice systems and guides for designing novel devices. Major advances in the ARPES studies of moiré superlattices are reviewed and new experimental directions are discussed.

The last decade has witnessed a flourish in 2D materials including graphene and transition metal dichalcogenides (TMDs) as atomic-scale Legos. Artificial moiré superlattices via stacking 2D materials with a twist angle and/or a lattice mismatch have recently become a fertile playground exhibiting a plethora of emergent properties beyond their building blocks. These rich quantum phenomena stem from their nontrivial electronic structures that are effectively tuned by the moiré periodicity. Modern angle-resolved photoemission spectroscopy (ARPES) can directly visualize electronic structures with decent momentum, energy, and spatial resolution, thus can provide enlightening insights into fundamental physics in moiré superlattice systems and guides for designing novel devices. In this review, first, a brief introduction is given on advanced ARPES techniques and basic ideas of band structures in a moiré superlattice system. Then ARPES research results of various moiré superlattice systems are highlighted, including graphene on substrates with small lattice mismatches, twisted graphene/TMD moiré systems, and high-order moiré superlattice systems. Finally, it discusses important questions that remain open, challenges in current experimental investigations, and presents an outlook on this field of research.

In this review, a series of bioprinting techniques, polymer-based inks, and bioprinted devices are presented for wound healing. Recent advances in this cutting-edge field, including seven modification strategies of bioprinted devices and the clinical needs they address are summarized and discussed. Several frontiers of bioprinting, challenges, and future directions are highlighted and prospected.

Bioprinting has attracted much attention due to its suitability for fabricating biomedical devices. In particular, bioprinting has become one of the growing centers in the field of wound healing, with various types of bioprinted devices being developed, including 3D scaffolds, microneedle patches, and flexible electronics. Bioprinted devices can be designed with specific biostructures and biofunctions that closely match the shape of wound sites and accelerate the regeneration of skin through various approaches. Herein, a comprehensive review of the bioprinting of smart wound dressings is presented, emphasizing the crucial effect of bioprinting in determining biostructures and biofunctions. The review begins with an overview of bioprinting techniques and bioprinted devices, followed with an in-depth discussion of polymer-based inks, modification strategies, additive ingredients, properties, and applications. The strategies for the modification of bioprinted devices are divided into seven categories, including chemical synthesis of novel inks, physical blending, coaxial bioprinting, multimaterial bioprinting, physical absorption, chemical immobilization, and hybridization with living cells, and examples are presented. Thereafter, the frontiers of bioprinting and wound healing, including 4D bioprinting, artificial intelligence-assisted bioprinting, and in situ bioprinting, are discussed from a perspective of interdisciplinary sciences. Finally, the current challenges and future prospects in this field are highlighted.

In this review, representative natural living materials and the strategies of introducing synthetic materials to tailor natural living materials for precision treatment of various diseases are systematically summarized, and challenges and future development are also discussed.

Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered living materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, and their active derivatives that are used for treating various diseases are summarized. Further, the future perspectives and challenges of such engineered living material-based biotherapeutics are discussed to provide considerations for future advances in biomedical applications.

Conversion-type cathode materials for aqueous Zn metal batteries in nonalkaline electrolytes can enable higher capacities and energy densities than conventional intercalated cathode materials. This review summarizes the reaction mechanisms, progress, challenges, and solutions of these four kinds of conversion-type cathode materials (MnO2, halogen materials, chalcogenide materials, and Cu-based compounds), and proposes some suggestions for their developments.

Aqueous Zn metal batteries are attractive as safe and low-cost energy storage systems. At present, due to the narrow window of the aqueous electrolyte and the strong reliance of the Zn2+ ion intercalated reaction on the host structure, the current intercalated cathode materials exhibit restricted energy densities. In contrast, cathode materials with conversion reactions can promise higher energy densities. Especially, the recently reported conversion-type cathode materials that function in nonalkaline electrolytes have garnered increasing attention. This is because the use of nonalkaline electrolytes can prevent the occurrence of side reactions encountered in alkaline electrolytes and thereby enhance cycling stability. However, there is a lack of comprehensive review on the reaction mechanisms, progress, challenges, and solutions to these cathode materials. In this review, four kinds of conversion-type cathode materials including MnO2, halogen materials (Br2 and I2), chalcogenide materials (O2, S, Se, and Te), and Cu-based compounds (CuI, Cu2O, Cu2S, CuO, CuS, and CuSe) are reviewed. First, the reaction mechanisms and battery structures of these materials are introduced. Second, the fundamental problems and their corresponding solutions are discussed in detail in each material. Finally, future directions and efforts for the development of conversion-type cathode materials for aqueous Zn batteries are proposed.

2D ferroic materials with ultrathin thickness and atomically smooth interface are promising candidates for constructing novel memory devices. This review surveys recent progress and proposes future prospects on 2D ferroic materials for nonvolatile memory applications, including 2D spintronic devices, 2D ferroelectric devices, and 2D multiferroic devices.

The emerging nonvolatile memory technologies based on ferroic materials are promising for producing high-speed, low-power, and high-density memory in the field of integrated circuits. Long-range ferroic orders observed in 2D materials have triggered extensive research interest in 2D magnets, 2D ferroelectrics, 2D multiferroics, and their device applications. Devices based on 2D ferroic materials and heterostructures with an atomically smooth interface and ultrathin thickness have exhibited impressive properties and significant potential for developing advanced nonvolatile memory. In this context, a systematic review of emergent 2D ferroic materials is conducted here, emphasizing their recent research on nonvolatile memory applications, with a view to proposing brighter prospects for 2D magnetic materials, 2D ferroelectric materials, 2D multiferroic materials, and their relevant devices.

This review investigates eight targeting strategies of functional materials that specifically target subcellular structures in tumor cells, including mitochondria, nucleus, endoplasmic reticulum, lysosome, Golgiosome, cytomembrane, and multi-organelle targeting strategies, and covers a wide range of functional materials, such as liposomes, metal nanoparticles, metal-organic frameworks, dendrimer nanoplatforms, carbon nanotubes, mitochondria-targeting mesoporous silica nanoparticles, carbon QD, amphiphilic copolymers, and small molecular compounds.

Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment. However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of cancer, genomic instability, and the formation of an immunosuppressive tumor microenvironment. Functional materials possess unique biological properties such as long circulation times, tumor-specific targeting, and immunomodulation. The combination of functional materials with natural substances and nanotechnology has led to the development of smart biomaterials with multiple functions, high biocompatibilities, and negligible immunogenicities, which can be used for precise cancer treatment. Recently, subcellular structure-targeting functional materials have received particular attention in various biomedical applications including the diagnosis, sensing, and imaging of tumors and drug delivery. Subcellular organelle-targeting materials can precisely accumulate therapeutic agents in organelles, considerably reduce the threshold dosages of therapeutic agents, and minimize drug-related side effects. This review provides a systematic and comprehensive overview of the research progress in subcellular organelle-targeted cancer therapy based on functional nanomaterials. Moreover, it explains the challenges and prospects of subcellular organelle-targeting functional materials in precision oncology. The review will serve as an excellent cutting-edge guide for researchers in the field of subcellular organelle-targeted cancer therapy.

The up-to-date growth strategies for the controlled synthesis of wafer-scale 2D semiconducting TMDCs polycrystalline and single-crystal films are systematically summarized. The large-area accurate doping of 2D semiconducting TMDCs and its effect on the device performances are discussed. The challenges regarding the improvement of electronic device performances of 2D semiconducting TMDCs are highlighted, and the further research directions are proposed.

2D semiconducting transition metal dichalcogenide (TMDCs) possess atomically thin thickness, a dangling-bond-free surface, flexible band structure, and silicon-compatible feature, making them one of the most promising channels for constructing state-of-the-art field-effect transistors in the post-Moore's era. However, the existing 2D semiconducting TMDCs fall short of meeting the industry criteria for practical applications in electronics due to their small domain size and the lack of an effective approach to modulate intrinsic physical properties. Therefore, it is crucial to prepare and dope 2D semiconducting TMDCs single crystals with wafer size. In this review, the up-to-date progress regarding the wafer-scale growth of 2D semiconducting TMDC polycrystalline and single-crystal films is systematically summarized. The domain orientation control of 2D TMDCs and the seamless stitching of unidirectionally aligned 2D islands by means of substrate design are proposed. In addition, the accurate and uniform doping of 2D semiconducting TMDCs and the effect on electronic device performances are also discussed. Finally, the dominating challenges pertaining to the enhancement of the electronic device performances of TMDCs are emphasized, and further development directions are put forward. This review provides a systematic and in-depth summary of high-performance device applications of 2D semiconducting TMDCs.

This paper discusses the photothermal properties and biological mechanisms of nanomaterials, emphasizing a clinical and biological perspective. The primary focus is on current research regarding photothermal nanoparticles for breast cancer treatment: nanoparticle materials, breast characteristics, functional design, and commonly used adjuvant therapy in clinical practice.

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location and aesthetic significance render breast cancer a particularly pertinent candidate for the clinical application of PTT following melanoma. This review comprehensively explores the research conducted on the various types of nanoparticles employed in PTT for breast cancer and elaborates on their specific roles and mechanisms of action. The integration of PTT with existing clinical therapies for breast cancer is scrutinized, underscoring its potential for synergistic outcomes. Additionally, the mechanisms underlying PTT and consequential modifications to the tumor microenvironment after treatment are elaborated from a medical perspective. Future research directions are suggested, with an emphasis on the development of integrative platforms that combine multiple therapeutic approaches and the optimization of nanoparticle synthesis for enhanced treatment efficacy. The goal is to push the boundaries of PTT toward a comprehensive, clinically applicable treatment for breast cancer.

Liver and kidney failure leads to the accumulation of toxic metabolites such as bilirubin, blood ammonia, endotoxin, and creatinine in the blood and tissues, which aggravate the progression of the disease. Hemoperfusion can effectively adsorb and remove toxins by extracorporeal system. Carbon materials, zeolites, MXenes, polymer materials, composite materials, porous materials, etc. have been developed as hemoperfusion adsorbents to remove common toxins in liver and kidney failure and to treat liver and kidney failure.

Liver and kidney failure can lead to extensive accumulation of toxic metabolites in the blood and tissues, such as bilirubin, blood ammonia, endotoxins, cytokines, creatinine, uric acid, and urea, which aggravate the progression of the disease. Hemoperfusion can effectively adsorb and remove toxins from the blood and treat liver and kidney failure. However, the adsorption efficiency and safety of traditional hemoperfusion adsorbents are not ideal. Thus, it is urgent to develop adsorbents with good blood compatibility, as well as high adsorption and strong selective capacities, to fulfill the clinical needs. In recent years, new hemoperfusion adsorbents with improved adsorption performance and good blood compatibility have been developed. This review classifies and summarizes the recent research progress in hemoperfusion adsorbents for common blood toxins (bilirubin, blood ammonia, endotoxins, cytokines, creatinine, uric acid, and urea) produced by liver and kidney failure. The composition and structure of various toxin adsorbents, toxin adsorption performance, biocompatibility, blood safety, and the adsorption mechanisms of toxins are discussed. Based on a summary of recent studies, feasible strategies have been explored for designing and preparing hemoperfusion adsorbents to fulfill future development requirements. The trends and clinical application prospects of various toxin adsorbents are also discussed.

Different strategies for nanoporous materials to specifically identify nucleic acids are explored. Their applications are emphasized in selective separation and detection of nucleic acids. They can also be used as DNA/RNA sensors, gene delivery agents, host DNAzymes, and in DNA-based computing. Other applications include catalysis, data storage, and biomimetics.

Nucleic acid plays a crucial role in countless biological processes. Hence, there is great interest in its detection and analysis in various fields from chemistry, biology, to medicine. Nanoporous crystalline materials exhibit enormous potential as an effective platform for nucleic acid recognition and application. These materials have highly ordered and uniform pore structures, as well as adjustable surface chemistry and pore size, making them good carriers for nucleic acid extraction, detection, and delivery. In this review, the latest developments in nanoporous crystalline materials, including metal organic frameworks (MOFs), covalent organic frameworks (COFs), and supramolecular organic frameworks (SOFs) for nucleic acid recognition and applications are discussed. Different strategies for functionalizing these materials are explored to specifically identify nucleic acid targets. Their applications in selective separation and detection of nucleic acids are highlighted. They can also be used as DNA/RNA sensors, gene delivery agents, host DNAzymes, and in DNA-based computing. Other applications include catalysis, data storage, and biomimetics. The development of novel nanoporous crystalline materials with enhanced biocompatibility has opened up new avenues in the fields of nucleic acid analysis and therapy, paving the way for the development of sensitive, selective, and cost-effective diagnostic and therapeutic tools with widespread applications.

Machine learning (ML) revolutionizes high entropy compounds (HECs) research, addressing their complex structures. It models HEC at atomic and macroscopic levels, using various algorithms. Accurate data, feature engineering, and cross-validation are key for robust models. ML's potential in HEC exploration is significant, driving Artificial-intelliegence-assisted material discovery.

Machine learning (ML) has emerged as a powerful tool in the research field of high entropy compounds (HECs), which have gained worldwide attention due to their vast compositional space and abundant regulatability. However, the complex structure space of HEC poses challenges to traditional experimental and computational approaches, necessitating the adoption of machine learning. Microscopically, machine learning can model the Hamiltonian of the HEC system, enabling atomic-level property investigations, while macroscopically, it can analyze macroscopic material characteristics such as hardness, melting point, and ductility. Various machine learning algorithms, both traditional methods and deep neural networks, can be employed in HEC research. Comprehensive and accurate data collection, feature engineering, and model training and selection through cross-validation are crucial for establishing excellent ML models. ML also holds promise in analyzing phase structures and stability, constructing potentials in simulations, and facilitating the design of functional materials. Although some domains, such as magnetic and device materials, still require further exploration, machine learning's potential in HEC research is substantial. Consequently, machine learning has become an indispensable tool in understanding and exploiting the capabilities of HEC, serving as the foundation for the new paradigm of Artificial-intelligence-assisted material exploration.

Intractable oral biofilms are the chief culprits of both dental infections and systemic inflammation, posing a great threat to human health. In this review, core strategies of recently developed biomaterials in eradicating oral biofilm are present. Furthermore, design rationales of biomaterials with advanced antibiofilm capacity, as well as versatile antibiofilm biomaterials with other functions are comprehensively summarized.

Oral biofilms, which are also known as dental plaque, are the culprit of a wide range of oral diseases and systemic diseases, thus contributing to serious health risks. The manner of how to achieve good control of oral biofilms has been an increasing public concern. Novel antimicrobial biomaterials with highly controllable fabrication and functionalization have been proven to be promising candidates. However, previous reviews have generally emphasized the physicochemical properties, action mode, and application effectiveness of those biomaterials, whereas insufficient attention has been given to the design rationales tailored to different infection types and application scenarios. To offer guidance for better diversification and functionalization of anti-oral-biofilm biomaterials, this review details the up-to-date design rationales in three aspects: the core strategies in combating oral biofilm, as well as the biomaterials with advanced antibiofilm capacity and multiple functions based on the improvement or combination of the abovementioned antimicrobial strategies. Thereafter, insights on the existing challenges and future improvement of biomaterial-assisted oral biofilm treatments are proposed, hoping to provide a theoretical basis and reference for the subsequent design and application of antibiofilm biomaterials.

Engineered living materials (ELMs) possess unique properties of self-replication, self-healing, and responsiveness to the environment. They are poised to bring revolutionary advancements in various fields including environmental remediation, construction industry, and renewable energy. An overview of the progress of synthetic biology-based ELMs from bacteria, fungi, and plants, along with challenges and future prospects, are provided.

At the intersection of synthetic biology and materials science, engineered living materials (ELMs) exhibit unprecedented potential. Possessing unique “living” attributes, ELMs represent a significant paradigm shift in material design, showcasing self-organization, self-repair, adaptability, and evolvability, surpassing conventional synthetic materials. This review focuses on reviewing the applications of ELMs derived from bacteria, fungi, and plants in environmental remediation, eco-friendly architecture, and sustainable energy. The review provides a comprehensive overview of the latest research progress and emerging design strategies for ELMs in various application fields from the perspectives of synthetic biology and materials science. In addition, the review provides valuable references for the design of novel ELMs, extending the potential applications of future ELMs. The investigation into the synergistic application possibilities amongst different species of ELMs offers beneficial reference information for researchers and practitioners in this field. Finally, future trends and development challenges of synthetic biology for ELMs in the coming years are discussed in detail.

This review focuses on the advance in flexible and stretchable electrochemical sensors (FSECSs) for biological monitoring. The fabrication of FSECSs with emphasis on stretchable electrodes and some key strategies for improving their performance is summarized. Then, their applications in exploring the chemical information from different biological entities, including epidermis, tissues both in vitro and in vivo, and cells, are highlighted.

The rise of flexible and stretchable electronics has revolutionized biosensor techniques for probing biological systems. Particularly, flexible and stretchable electrochemical sensors (FSECSs) enable the in situ quantification of numerous biochemical molecules in different biological entities owing to their exceptional sensitivity, fast response, and easy miniaturization. Over the past decade, the fabrication and application of FSECSs have significantly progressed. This review highlights key developments in electrode fabrication and FSECSs functionalization. It delves into the electrochemical sensing of various biomarkers, including metabolites, electrolytes, signaling molecules, and neurotransmitters from biological systems, encompassing the outer epidermis, tissues/organs in vitro and in vivo, and living cells. Finally, considering electrode preparation and biological applications, current challenges and future opportunities for FSECSs are discussed.

In this review, the recent advances on lipid nanoparticles (LNPs) for precision diagnosis and treatment of renal cell carcinoma (RCC) are comprehensively summarized. The chemical compositions of LNPs and the modification strategies for enhanced tumor target are introduced. After that, the authors’ ongoing and foreseeable biomedical applications are discussed and prospected.

Renal cell carcinoma (RCC) is a common urological malignancy and represents a leading threat to healthcare. Recent years have seen a series of progresses in the early diagnosis and management of RCC. Theranostic lipid nanoparticles (LNPs) are increasingly becoming one of the focuses in this field, because of their suitability for tumor targeting and multimodal therapy. LNPs can be precisely fabricated with desirable chemical compositions and biomedical properties, which closely match the physiological characteristics and clinical needs of RCC. Herein, a comprehensive review of theranostic LNPs is presented, emphasizing the generic tool nature of LNPs in developing advanced micro-nano biomaterials. It begins with a brief overview of the compositions and formation mechanism of LNPs, followed with an introduction to kidney-targeting approaches, such as passive, active, and stimulus responsive targeting. With examples provided, a series of modification strategies for enhancing the tumor targeting and functionality of LNPs are discussed. Thereafter, research advances on applications of these LNPs for RCC including bioimaging, liquid biopsy, drug delivery, physical therapy, and gene therapy are summarized and discussed from an interdisciplinary perspective. The final part highlights the milestone achievements of translation medicine, current challenges as well as future development directions of LNPs for the diagnosis and treatment of RCC.

Recent advances in intrinsically chiral plasmonic nanomaterials have provided great opportunities for many promising applications. Here, the geometric control and optical properties of chiral plasmonic nanomaterials are circumnavigated and widen the scope of their potential applications. It is envisioned that these studies will pave the way toward the rational design of chiral nanomaterials with desired optical properties for emerging applications.

Intrinsically chiral plasmonic nanomaterials exhibit intriguing geometry-dependent chiroptical properties, which is due to the combination of plasmonic features with geometric chirality. Thus, chiral plasmonic nanomaterials have become promising candidates for applications in biosensing, asymmetric catalysis, biomedicine, photonics, etc. Recent advances in geometric control and optical tuning of intrinsically chiral plasmonic nanomaterials have further opened up a unique opportunity for their widespread applications in many emerging technological areas. Here, the recent developments in the geometric control of chiral plasmonic nanomaterials are reviewed with special attention given to the quantitative understanding of the chiroptical structure-property relationship. Several important optical spectroscopic tools for characterizing the optical chirality of plasmonic nanomaterials at both ensemble and single-particle levels are also discussed. Three emerging applications of chiral plasmonic nanomaterials, including enantioselective sensing, enantioselective catalysis, and biomedicine, are further highlighted. It is envisioned that these advanced studies in chiral plasmonic nanomaterials will pave the way toward the rational design of chiral nanomaterials with desired optical properties for diverse emerging technological applications.

This review mainly discusses the molecular aggregation science behind luminescence materials. From the basic packing modes of adjacent molecules to the various aggregated structures, the efficient bridge between molecular structures and luminescence property has been roughly built to promote their development from internal to external.

The luminescence materials act as the key components in many functional devices, as well as the detection and imaging systems, which can be permeated in each aspect of modern life, and attract more and more attention for the creative technology and applications. In addition to the diverse properties of organic luminogens, the multiple molecular packing at aggregated states frequently offers new and/or exciting performance. However, there still lacks comprehensive analysis of molecular packing in these organic materials, resulting in an increased gap between molecular design and practical applications. In this review, from the basic knowledge of organic compounds as single molecules, to the discernable property of excimer, charge transfer (CT) complex or self-assembly systems by adjacent molecules, and finally to the opto-electronic performance of molecular aggregates, the relevant factors to molecular packing and practical applications are discussed.