Fri 09 May 14:00: Title to be confirmed
Abstract not available
- Speaker: Manon Thbaut, Ecole polytechnique
- Friday 09 May 2025, 14:00-15:00
- Venue: Oatley 1 Meeting Room, Department of Engineering.
- Series: Engineering - Mechanics and Materials Seminar Series; organiser: div-c.
The Influence of Ionizing Radiation on Quantification for In Situ and Operando Liquid‐Phase Electron Microscopy
Liquid-phase transmission electron microscopy enables visualization of nanoscale processes involving liquid media. Yet, it suffers from beam effects, such as radiolysis of the liquid, sample heating, and membrane charging. This review summarizes beam effect fundamentals, describes modeling and assessment, and illustrates handling strategies. The findings are transferable to other ionizing radiation techniques using, for example, γ- or X-rays.
Abstract
The ionizing radiation harnessed in electron microscopes or synchrotrons enables unique insights into nanoscale dynamics. In liquid-phase transmission electron microscopy (LP-TEM), irradiating a liquid sample with electrons offers access to real space information at an unmatched combination of temporal and spatial resolution. However, employing ionizing radiation for imaging can alter the Gibbs free energy landscape during the experiment. This is mainly due to radiolysis and the corresponding shift in chemical potential; however, experiments can also be affected by irradiation-induced charging and heating. In this review, the state of the art in describing beam effects is summarized, theoretical and experimental assessment guidelines are provided, and strategies to obtain quantitative information under such conditions are discussed. While this review showcases these effects on LP-TEM, the concepts that are discussed here can also be applied to other types of ionizing radiation used to probe liquid samples, such as synchrotron X-rays.
Tue 25 Feb 17:00: Along the thread of the mosquito ovary: apprehending malarias lost and regained
Abstract not available
- Speaker: Ann Kelly (University of Oxford)
- Tuesday 25 February 2025, 17:00-18:30
- Venue: Seminar Room 1, Department of History and Philosophy of Science.
- Series: History of Modern Medicine and Biology; organiser: Nick Hopwood.
Thu 06 Mar 11:00: 2025 Scott Lectures - Lecture 3 Title tbc
Abstract not available
- Speaker: Professor Mikhail Lukin, Harvard University
- Thursday 06 March 2025, 11:00-12:00
- Venue: Ray Dolby Auditorium, Ray Dolby Centre, Cavendish Laboratory, JJ Thomson Avenue, CB3 0US.
- Series: Scott Lectures; organiser: Leona Hope-Coles.
Mon 03 Mar 16:00: 2025 Scott Lectures - Lecture 1 Title tbc Drinks and nibbles will be served after the lecture
Abstract not available
Drinks and nibbles will be served after the lecture
- Speaker: Professor Mikhail Lukin, Harvard University
- Monday 03 March 2025, 16:00-17:00
- Venue: Ray Dolby Auditorium, Ray Dolby Centre, Cavendish Laboratory, JJ Thomson Avenue, CB3 0US.
- Series: Scott Lectures; organiser: Leona Hope-Coles.
Wed 05 Mar 16:00: 2025 Scott Lectures - Lecture 2 Title tbc Drinks and nibbles will be served after the lecture
Abstract not available
Drinks and nibbles will be served after the lecture
- Speaker: Professor Mikhail Lukin, Harvard University
- Wednesday 05 March 2025, 16:00-17:00
- Venue: Ray Dolby Auditorium, Ray Dolby Centre, Cavendish Laboratory, JJ Thomson Avenue, CB3 0US.
- Series: Scott Lectures; organiser: Leona Hope-Coles.
Thu 06 Mar 17:00: Title to be confirmed POSTPONED
=== Hybrid talk ===
Join Zoom Meeting https://cam-ac-uk.zoom.us/j/87143365195?pwd=SELTNkOcfVrIE1IppYCsbooOVqenzI.1
Meeting ID: 871 4336 5195
Passcode: 541180
POSTPONED
- Speaker: Andrei Popescu (University of Sheffield)
- Thursday 06 March 2025, 17:00-18:00
- Venue: MR14 Centre for Mathematical Sciences.
- Series: Formalisation of mathematics with interactive theorem provers ; organiser: Anand Rao Tadipatri.
Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth
Nature Nanotechnology, Published online: 21 February 2025; doi:10.1038/s41565-025-01867-7
Delivering therapeutics to the brain is challenging because of the hard-to-cross blood–brain barrier. Here, the authors show that HER3, which is expressed on the surface of many metastatic tumours, is associated with the brain endothelium and can drive accumulation of HER3-targeted nanoparticles within the brain, for therapy against HER3-positive tumours.Intermediate-range solvent templating and counterion behaviour at charged carbon nanotube surfaces
Nature Nanotechnology, Published online: 21 February 2025; doi:10.1038/s41565-025-01865-9
Neutron scattering on a model system of highly concentrated solutions of charged carbon nanotubes reveals a strong solvent ordering up to ∼40 Å around the charged nanoscale surface.Rolling carbon on a rock
Nature Materials, Published online: 21 February 2025; doi:10.1038/s41563-025-02151-8
A method is reported to create chiral rolls from two-dimensional atomic layers such as graphene with controlled rolling angles, which show optical activity and spin-selective transport dependent on the chiral lattice structures.When stars make loopy networks
Nature Materials, Published online: 21 February 2025; doi:10.1038/s41563-025-02157-2
The high-frequency elastic response reveals interpenetrated and polycatenated structures in DNA nanostar network materials.Origins of elasticity in molecular materials
Nature Materials, Published online: 21 February 2025; doi:10.1038/s41563-025-02133-w
Elasticity is ubiquitous in everyday life, but the molecular origin of the restoring force remains elusive. Here the authors use a series of density functional theory calculations to understand how interaction energies change as a result of the bending of molecular crystals.Graphene rolls with tunable chirality
Nature Materials, Published online: 21 February 2025; doi:10.1038/s41563-025-02127-8
A wax-aided immersion methodology is developed to yield graphene rolls with tunable chiral angles; these graphene rolls exhibit promising chiral electronic properties beyond those of other carbon allotropes.Faster deployment of renewables stabilizes electricity prices in Europe
Nature Energy, Published online: 21 February 2025; doi:10.1038/s41560-025-01715-x
Increasing solar photovoltaic and wind generation capacity beyond European 2030 targets could make electricity prices more stable, with reductions in sensitivity to fluctuations in the price of natural gas possibly outweighing the increasing influence of weather effects. Energy policies should account for the macroeconomic benefits of more stable energy prices as an important motivation for the deployment of renewables, in addition to their contribution to the mitigation of climate change.Multi-country evidence on societal factors to include in energy transition modelling
Nature Energy, Published online: 21 February 2025; doi:10.1038/s41560-025-01719-7
Mitigation scenarios are required to account for societal factors. Fisch-Romito et al. integrate factors related to infrastructure, actors’ decision-making and socio-institutional context into a national energy model, and, using hindcasting, show how this can improve the modelled pathways.Thu 20 Feb 17:00: Formalising Brauer Group and Group Cohomology in Lean4
The concept of Brauer Groups, originally developed to classify division algebras, has now found many uses in scheme theory and class field theory. Brauer Groups over a field k is defined as the collection of central simple algebras over k modulo certain equivalence relations and this project is set out to formalise the correspondence between the Brauer groups and the second Galois cohomology groups Br(k) ≅ H²(Gal(k_sep/k) , k ⃰_sep). In this talk, we give a complete formalisation between the relative Brauer group of a finite dimensional field extension Br(K/k) and the second group cohomology H²(Gal (K/k) , K ⃰) as the first step.
Github Repository: https://github.com/Whysoserioushah/BrauerGroup_new
- Speaker: Jujian Zhang (Imperial College London)
- Thursday 20 February 2025, 17:00-18:00
- Venue: MR14 Centre for Mathematical Sciences.
- Series: Formalisation of mathematics with interactive theorem provers ; organiser: Anand Rao Tadipatri.
Thu 06 Mar 16:00: “Self-protection of the early embryo: a dynamic perspective on phagocytosis in natural environments”
Early embryogenesis is a highly plastic stage, capable of overcoming a wide range of perturbations. Significant efforts have been dedicated to understanding how pluripotent cells adapt their developmental programs in response to deviations. However, how the embryo protects its cells from these perturbations without possessing its own immune system remains poorly understood. Our previous research revealed that epithelial cells on the embryonic surface (trophectoderm in mammals) can eliminate apoptotic cells through phagocytosis. Here, I will present our latest findings demonstrating that the early embryo can also clear infectious agents. Using a quantitative live imaging approach, we investigate this process across biological scales in zebrafish, mouse, and human embryos. Additionally, our model serves as a platform to study the phagocytic dynamics of microorganisms carried out by epithelial tissues in natural environments.
- Speaker: Dr Esteban Hoijman. Embryonic Cell Bioimaging lab, Molecular Biology Institute of Barcelona, IBMB-CSIC/IDIBELL
- Thursday 06 March 2025, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology building, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: foster.
Thu 06 Mar 16:00: “Self-protection of the early embryo: a dynamic perspective on phagocytosis in natural environments”
Early embryogenesis is a highly plastic stage, capable of overcoming a wide range of perturbations. Significant efforts have been dedicated to understanding how pluripotent cells adapt their developmental programs in response to deviations. However, how the embryo protects its cells from these perturbations without possessing its own immune system remains poorly understood. Our previous research revealed that epithelial cells on the embryonic surface (trophectoderm in mammals) can eliminate apoptotic cells through phagocytosis. Here, I will present our latest findings demonstrating that the early embryo can also clear infectious agents. Using a quantitative live imaging approach, we investigate this process across biological scales in zebrafish, mouse, and human embryos. Additionally, our model serves as a platform to study the phagocytic dynamics of microorganisms carried out by epithelial tissues in natural environments.
- Speaker: Dr Esteban Hoijman. Embryonic Cell Bioimaging lab, Molecular Biology Institute of Barcelona, IBMB-CSIC/IDIBELL
- Thursday 06 March 2025, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology building, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: foster.
Thu 06 Mar 16:00: “Self-protection of the early embryo: a dynamic perspective on phagocytosis in natural environments”
Early embryogenesis is a highly plastic stage, capable of overcoming a wide range of perturbations. Significant efforts have been dedicated to understanding how pluripotent cells adapt their developmental programs in response to deviations. However, how the embryo protects its cells from these perturbations without possessing its own immune system remains poorly understood. Our previous research revealed that epithelial cells on the embryonic surface (trophectoderm in mammals) can eliminate apoptotic cells through phagocytosis. Here, I will present our latest findings demonstrating that the early embryo can also clear infectious agents. Using a quantitative live imaging approach, we investigate this process across biological scales in zebrafish, mouse, and human embryos. Additionally, our model serves as a platform to study the phagocytic dynamics of microorganisms carried out by epithelial tissues in natural environments.
- Speaker: Dr Esteban Hoijman. Embryonic Cell Bioimaging lab, Molecular Biology Institute of Barcelona, IBMB-CSIC/IDIBELL
- Thursday 06 March 2025, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology building, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: foster.
Wed 05 Mar 13:00: Do microbiomes of parasitic nematodes contribute to disease pathogenesis?
Recently we have discovered that 70% of parasitic nematodes host a large and diverse RNA virome (Quek et al. 2024, Nature Microbiology). Previous work in our laboratory has highlighted the contribution of Wolbachia bacterial endosymbionts as drivers of inflammatory disease pathogenesis. Does the newly discovered RNA virome also contribute to disease pathogenesis? We have focussed on a rhabdovirus, OVRV1 , which is ubiquitous in endemic onchocerciasis populations and elicits antibody responses in infected or exposed communities. OVRV1 is phylogenetically related to lyssaviruses, including rabies, and as such may contribute to the disease pathogenesis of onchocerciasis associated epilepsy. To determine the fusogenicity and the resulting tropism of OVRV1 glycoprotein (gp) we have created lentiviral pseudotypes decorated with OVRV1 glycoproteins to define human cell susceptibility to infection. Pseudotyped lentiviruses provide an opportunity for rapid throughput to determine the functionality of putative viral glycoproteins, as well as provide mechanistic and tropism information in the absence of isolated infectious virus. To probe for cell susceptibility to OVRV1 gp-mediated entry, we exposed human cell lines of different origins (IRF3 KO lung epithelial A549 cells, embryonic kidney HEK293T cells and TZM -bl cells, a derivate of human cervix carcinoma HeLa cells) to GFP -encoding lentiviral particles decorated with OVRV1 -gp. Subsequently, we quantified reporter expression two days post-transduction, with vesicular stomatitis virus (VSV)-gp pseudotypes used as positive control and rhabdoviral reference. Addition of OVRV1 -gp lentiviral pseudotypes to cells generated GFP expression in a dose-dependent manner, providing robust evidence for the ability of OVRV1 gp to mediate entry into human cells and strengthening our hypothesis of OVRV1 infection-induced pathogenesis in humans. Current experiments are testing the susceptibility of advanced human induced pluripotent stem cells (iPSC)-derived bi/tri-partite neurospheroid culture systems to determine OVRV1 infection of neural cells and tissues.
- Speaker: Professor Mark Taylor, Liverpool School of Tropical Medicine
- Wednesday 05 March 2025, 13:00-14:00
- Venue: Seminar Room, Tennis Court Road, Dept of Pathology..
- Series: Parasitology Seminars; organiser: Maria Duque-Correa, mad75.